Chlorella-Loaded Antibacterial Microneedles for Microacupuncture Oxygen Therapy of Diabetic Bacterial Infected Wounds

Shuna Gao, Yu Rao, Xiaowei Wang, Qiuyang Zhang, Zijun Zhang, Yuxuan Wang, Jiangna Guo*（郭江娜）, Feng Yan*（严锋）

Jiangsu Engineering Laboratory of Novel Functional Polymeric Materials, Jiangsu Key Laboratory of Advanced Negative Carbon Technologies,Suzhou Key Laboratory of Soft Material and New Energy, College of Chemistry Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China

Adv. Mater. 2024, 36, 2307585 (1 of 12)

Abstract: Hypoxia and infection are urgent clinical problems in chronic diabetic wounds. Herein, living Chlorella-loaded poly(ionic liquid)-based microneedles (PILMN-Chl) are constructed for microacupuncture oxygen and antibacterial therapy against methicillin-resistant Staphylococcus aureus (MRSA)-infected chronic diabetic wounds. The PILMN-Chl can stably and continuously produce oxygen for more than 30 h due to the photosynthesis of the loaded self-supported Chlorella. By combining the barrier penetration capabilities of microneedles, the continuous and sufficient oxygen supply of Chlorella, and the sterilization activities of PIL, the PILMN-Chl can accelerate chronic diabetic wounds in vivo by topical targeted sterilization and hypoxia relief in deep parts of wounds. Thus, the self-oxygen produced microneedles modality may provide a promising and facile therapeutic strategy for treating chronic, hypoxic, and infected diabetic wounds.

链接：https://onlinelibrary.wiley.com/doi/10.1002/adma.202307585